According to the Simple View of intentional action famously refuted by Bratman, φ-ing is intentional only if the agent intended to φ. In this paper I show that none of five different objections to Bratman's counter-example – McCann's, Garcia's, Sverdlik's, Stout's, and Adams's – works. Therefore Bratman's contention that SV is false still stands.

Frankfurt sets out to refute the principle according to which ‘a person is morally responsible for what he has done only if he could have done otherwise’. Frankfurt devises a counterexample in which an agent is intuitively responsible even though she could not have done otherwise: Suppose someone – Black, let us say – wants Jones to perform a certain action. Black is prepared to go to considerable lengths to get his way, but he prefers to avoid showing his hand (...) unnecessarily. So he waits until Jones is about to make up his mind what to do, and he does nothing unless it is clear to him that Jones is going to decide to do something other than what he wants him to do. If it does become clear that Jones is going to decide to do something else, Black takes effective steps to ensure that Jones decides to do, and that he does do, what he wants him to do. Whatever Jones's initial preferences and inclinations, then, Black will have his way … Now suppose that Black never has to show his hand because Jones, for reasons of his own, decides to perform and does perform the very action Black wants him to perform. In that case, it seems clear, Jones will bear precisely …. (shrink)

The role of the microenvironment in cancer development is being increasingly appreciated. This paper will review data that highlight an emerging distinction between two different entities: the microenvironment that altered/preneoplastic/neoplastic cells find in the tissue where they reside, and the peculiar microenvironment inside the focal lesion (tumor) that these cells contribute to create. While alteration in the tissue environment can contribute to the selective clonal expansion of altered cells to form focal proliferative lesions, the atypical, non‐integrated growth pattern that defines (...) such focal lesions leads to the appearance of what is correctly referred to as the tumor microenvironment. The latter represents a new and unique biological milieu, characterized by hypoxia, acidosis and other biochemical and metabolic alterations, including genetic instability, that can set the stage for tumor progression to occur. Thus, the two microenvironments act in sequence and play complementary roles in the development of overt neoplasia. This distinction has important implications for the understanding of disease pathogenesis and for the management of preneoplastic/neoplastic lesions at various stages of cancer development. BioEssays 29:738–744, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Les designers et théoriciens Ezio Manzini et Virginia Tassinari répondent à la question posée par le titre du dossier, Design is the answer, but what was the question? Si, d’une part, se pose la question de l’impact social et politique du design et de sa responsabilité dans les changements sociaux, de l’autre s’impose une réflexion sur les modes d’action du design et sur les fondements de cette action. Dans cette perspective, Manzini met en avant les pratiques d’ engendrement et (...) d’ engagement comme stratégies d’action communes et communautaires, alors que Tassinari explique comment la définition du designing (plus que du design) comme une action politique nécessite une remise en question du cadre épistémologique qui la fonde. (shrink)

Cohen deals with the question of the possibility for art to represent God or the divine in some of his works, throughout all his philosophical production, but obviously above all in his main aesthetic work, sthetik des reinen Gefhls. We can state that in Cohen's works this problem is posed with reference to three different religious fields: Greek polytheism, Jewish monotheism and Christianity. The topic of this essay will be Cohen's thought about the artistic representation of the divine in Christianity (...) or in Christian art through the representation of Jesus. This topic will be examined with reference both to Kants Begrndung der sthetik and to sthetik des reinen Gefhls ; whereas in Kants Begrndung der sthetik Cohen devotes to the representation of Jesus just a short consideration in the historical introduction of the book, in sthetik des reinen Gefhls the representation of Jesus is object of far more attention. Here, Cohen's answer to the question of the possibility to represent the divine through the representation of Jesus is that Jesus' divinity, in the artistic representation of his figure, can only have a metaphorical value, the real meaning of which is that Jesus' story is the ideal story of the human being; in Kants Begrndung der sthetik and in other writings of the 80s, on the contrary, the idea of incarnation and of the divinity of Jesus is object of a different appreciation by Cohen. The comparison between these different stances can be a contribution to the comprehension of the changes in Cohen's view of Christianity through the years. (shrink)

La dimension immatérielle de notre réalité, grâce aux prothèses informatiques et médiatiques, est devenue de plus en plus étendue et puissante. Cet article suggère que la prétendue « dématérialisation » comporte le recel des conditions matérielles nécessaires à son propre essor. Il examine le rôle joué par la logistique dans ce processus de refoulement systématique de la jointure entre matériel et immatériel. Permettant que la marchandise puisse « apparaître » presque magiquement sur les rayons des magasins ou directement chez nous, (...) et que les déchets puissent « disparaître » tout aussi magiquement, l’organisation logistique actuelle repose sur un mix unique de transparence et d’opacisation. (shrink)

The digital revolution has generated huge changes in the world of work, with relevant implications for the Human Resources Management function. New challenges arise in facing digital work, digital employees, and digital management, such that the connection between new technologies and HRM is now described as electronic HRM. Challenges and connection entail the possibility to review the notion of HRM itself, examining new research perspectives and lines of interpretation following a Critical Management Studies approach, thus developing a more contextualized view (...) in conceiving HRM, a more expansive consideration of stakeholders, and a longer-term perspective in approaching the results of digital transformation and HRM outcomes. The article analyzes a specific organizational case, involving a multinational enterprise, and explores how the case study enhances the understanding of HRM as a social practice embedded in specific situated contexts. Such a conception enables the engagement of multiple rationalities, related to both internal and external stakeholders, overcoming a “mere antiperformance stance” and achieving forms of reconstructive reflexivity concerning the interconnection between the digital age, HRM, and the innovative generation of social value through an authentic corporate responsibility. (shrink)

Franz Rosenzweig devoted particular attention to the problem of individuality in Hermann Cohen’s philosophy. He writes that, in comparison with the individuality of the man of religion, “the human being about which aesthetics knew [...] fades now in all its aesthetic individuality to a ‘mere type’”. This statement is actually based on Cohen’s writings: in Ästhetik des reinen Gefühls, Cohen explicitly maintains that the human being that is the object of artistic representation is not a type, but rather an individual. (...) Just three years later, however, in his first book about philosophy of religion, Der Begriff der Religion im System der Philosophie, Cohen states that the human being that is represented by art is not really an individual; only the man of religion is really individual; the human being represented by art is merely a type. In this paper my aim is to argue for the thesis that these opposite statements belong to different points of view. From an aesthetic point of view the human being represented by art has to be considered as truly individual, but the systematic overview adopted in Der Begriff der Religion can teach us that the individuality of the human being represented by art can’t be maintained from a different point of view than the aesthetic one. (shrink)

Der Aufsatz sucht die Berechtigung der Leibnizschen Unterscheidung zwischen notwendigen und kontingenten Aussagen nachzuweisen. Das entscheidende Problem ist für den Autor die Frage nach der Verbindung zwischen dem Subjektbegriff und seinen Teilbegriffen, Teilbegriffe, ohne die der Subjektbegriff nicht gedacht werden kann, kommen ihm wesentlich und notwendig zu. Teilbegriffe, deren Zukommen jedoch nur bei Hinzunahme externer Bedingungen -letzlich des göttlichen Willens und seiner Wahl der besten Welt -begründet werden kann, kommen in kontingenter Weise zu. Notwendige Sätze können durch eine Analyse der (...) Begriffe in endlich vielen Schritten bewiesen werden, kontingente Sätze erfordern eine unendliche Analyse und sind deshalb nicht beweisbar. Leibniz' Annahme kontingenter Aussagen beruht daher nach der Überzeugung des Autors nicht auf der Unterscheidung zwischen Möglichkeit und Existenz, wie z. B. Russell geglaubt hat, sondern auf der Unterscheidung von Wesensbegriffen und Individualbegriffen. Mit Hilfe dieser Unterscheidung ist die Annahme kontingenter Aussagen nach der Meinung des Autors zu rechtfertigen. (shrink)

Partiendo de una serie de tesis respecto del significado de la negación lógica, se ofrece una reflexión acerca de la relación entre el pluralismo lógico y el estatus de ciertos principios lógicos fundamentales. El objetivo de este trabajo es mostrar que el Problema de la Adopción, tal como se encuentra formulado por Kripke-Padró, no representa un conflicto para una visión antiexcepcionalista de la lógica. Las leyes lógicas no poseen un status privilegiado, independientemente de que existan algunas que no podemos adoptar, (...) porque sí podemos decidir abandonar principios lógicos y es abandonando reglas y no adoptándolas como se revisa una teoría lógica; en consecuencia es aceptable un tipo de pluralismo lógico que parta de considerar que más de un conjunto de principios capturan de manera adecuada el significado de la negación. (shrink)

“The Messiah [...] is the source of all religious art.” This statement, which we find in Cohen’s Über den ästhetischen Wert unserer religiösen Bildung, seems to be not fully consistent with the whole of Cohen’s aesthetics and with Cohen’s thought about the possibility of art having religious themes. In order to explain this statement and Cohen’s perspective about Messianism in art, in §§ 1-3 I examine Cohen’s reflections about this topic in his main works about art and religion; in § (...) 4 I maintain that the goal of this statement is to underline a difference between Jewish and Christian religious art. Finally, in § 5, I offer a short examination of some 20th or 21th century artworks that can be compared to Cohen’s views about Messianism in art: namely, Marc Chagall’s crucifixions, Gustav Mahler’s 4th symphony, and Michelangelo Pistoletto’s Terzo Paradiso. (shrink)

This paper is about Michel Henry’s interpretation of the topic of the soul in Kant’s thought. Two aspects of this topic will be particularly examined: Kant’s criticism of the concept of the soul as a substance and the I think as the consciousness that every representation of mine is a representation for me. Henry thinks that the insertion of this consciousness in Kant’s thought is a necessary incoherence that shows the impossibility to reduce appearing to representation. At the end it (...) will be shown that, in the context of henrian thought, the abandonment of the concept of the soul as a substance is a condition to assert the radical difference between human beings and things. (shrink)

1. Elementi metodologici e storici.--2. Struttura logico-dialettica dell'esperienza morale.

The correspondence between Leibniz and Samuel Clarke was probably the most famous and influential philosophical exchange of the eighteenth century. It focused on the clash between the Newtonian and Leibnizian world systems, involving disputes in physics, theology, and metaphysics. Vailati's book provides a comprehensive overview and commentary on this important body of letters. He not only identifies and evaluates the various arguments, but situates the views advanced by the correspondence in the context of their principal writings.

Este livro poderia de facto definir-se também "Razão e Lógicas da Totalidade do Real na filosofia africana contemporânea". Quatro objectivos, por assim dizer, se vislumbram logo duma leitura atenta deste texto: antes de mais a preocupação dos autores de propor nos nossos dias, uma leitura transversal da filosofia africana moderna e contemporânea a partir, diríamos, do conceito da "razão". Trata-se, neste caso, de introduzir os leitores não na história da filosofia africana como tal, mas somente, como especifica Ezio Bono, (...) de delinear "algumas questões principais que consideram ser mais significativas e recorrentes no actual debate" da filosofia africana moderna e contemporânea e a sua "traversée" (Bidima), por assim dizer, no âmbito moçambicano (José Castiano). Este texto, cuja vocação principal é transformar-se, "grosso modo", numa espécie de "Humanidades Clássicas Africanas" (Cheikh Anta Diop), se quer sintético e ao mesmo tempo panorâmico. Ele é sintético, pois os autores partem duma leitura temática (a razão). Ele é também panorâmico, já que partindo deste focus temático, eles oferecem uma visão global desta matéria, do ponto de vista histórico, teorético, epistemológico, cultural, panafricano (Procesi) e particular moçambicano (Bono e Castiano). (shrink)

Conhecido por textos que promoveram uma concepção autônoma de obra de arte, Karl Philipp Moritz foi também um destacado representante da tradição da psicologia – posições que pareceriam contraditórias a princípio, quando assumimos o desenvolvimento da estética na segunda metade do século XVIII. Seu ensaio Sobre a imitação formadora do belo possibilita, todavia, uma compreensão mais matizada da passagem entre essas perspectivas. Partindo de uma análise psicológica “profunda”, por assim dizer, da produtividade artística, Moritz aponta para uma força plástica e (...) objetiva atuante na subjetividade criadora, anterior à força representativa e dotada de sua própria lógica e linguagem. (shrink)

Chucho is an Andean bear who had lived most of his life in semicaptivity in a nature reserve in Manizales, Colombia. After his sister’s death, he became severely depressed, so the environmental authority transferred him to Barranquilla Zoo. A local lawyer filed a writ of habeas corpus based on Chucho’s right as a sentient being to live in his natural habitat. This writ has triggered a complex debate on nonhuman animal legal personhood and animal rights between two of the highest (...) courts in the country: the Supreme Court of Justice and the Constitutional Court. (shrink)

Samuel Clarke was by far the most gifted and influential Newtonian philosopher of his generation, and A Demonstration of the Being and Attributes of God, which constituted the 1704 Boyle Lectures, was one of the most important works of the first half of the eighteenth century, generating a great deal of controversy about the relation between space and God, the nature of divine necessary existence, the adequacy of the Cosmological Argument, agent causation, and the immateriality of the soul. Together with (...) the other texts presented in this edition, it also provides the best introduction to Clarke's philosophical views, which, in addition to their intrinsic interest, are historically important for the light they shed both on the philosophical positions within the Newtonian circle and on the exchange between Clarke and Leibniz, the most famous philosophical controversy of the eighteenth century. (shrink)

In higher eukaryotes, circadian behaviour patterns have been dissected at the molecular level in Drosophila and, more recently, in the mouse. Considerable progress has been made in identifying some of the molecular components of the clock in the fly, where two genes, period (per) and timeless (tim), are essential for behavioural rhythmicity. The PER and TIM proteins show circadian cycles in abundance, and are part of a negative feedback loop with their own mRNAs. Within the pacemaker neurons, the PER and (...) TIM products are believed to form a complex which allows them to translocate to the nucleus, but how they repress their own transcription is unclear. TIM is rapidly degraded by light, a feature which permits a compelling molecular description of both behavioural light entrainment and phase responses to light pulses. The regulation of per and tim is altered in different Drosophila tissues, however, and comparative analyses of the two genes outside the Diptera reveals further unusual patterns of tissue‐specific regulation. Evolution appears to have modified the way in which the two genes are utilised to generate circadian phenotypes. More recently, the cloning of mouse clock genes, including putative per homologues, opens up exciting possibilities for mammalian molecular chronobiology. (shrink)

In this paper I refute an apparently obvious objection to Frankfurt-type counterexamples to the Principle of Alternate Possibilities according to which if in the counterfactual scenario the agent does not act, then the agent could have avoided acting in the actual scenario. And because what happens in the counterfactual scenario cannot count as the relevant agent's actions given the sort of external control that agent is under, then we can ground responsibility on that agent having been able to avoid acting. (...) I illustrate how this objection to Frankfurt's famous counterexample is motivated by Frankfurt's own 'guidance' view of agency. My argument consists in showing that even if we concede that the agent does not act in the counterfactual scenario, that does not show that the agent could have avoided acting in the actual scenario. This depends on the crucial distinction between 'not φ-ing' and 'avoiding φ-ing'. (shrink)

According to the Simple View of intentional action famously refuted by Bratman , φ-ing is intentional only if the agent intended to φ. In this paper I show that none of five different objections to Bratman's counter-example – McCann's , Garcia's , Sverdlik's , Stout's , and Adams's – works. Therefore Bratman's contention that SV is false still stands.

Interaction between geology and mining was a decisive element for the development of stratigraphy during the eighteenth century in Germany, Sweden, England, and also Italy. This paper analyses the importance of mining background and experience, and interest in mining, among some eighteenth-century Italian scholars who studied mountains and other terrestrial reliefs paying particular attention to their rocks, strata and formations. Several primary sources are examined, from the early case of Antonio Vallisneri-who, being a physician, used the mines and the quarries (...) as necessary tools of his 'anatomy' of the mountains-up to the geological travels in the Alps and the Apennines promoted in the late eighteenth century with mining perspectives. Rigorous empirical approaches to the study of the Earth's surface-shown by scientists such as Luigi Ferdinando Marsili, Giovanni Targioni Tozzetti and Giovanni Arduino-are here investigated in the light of their mining expertise. This practical knowledge was an essential element of their theoretical work on the 'classification' of mountains. (shrink)